SCOP 1.73: Domain d1rt3a2: 1rt3 A:2-429

Lineage for d1rt3a2 (1rt3 A:2-429)

1. Root: SCOP 1.73

2. Class e: Multi-domain proteins (alpha and beta) [56572] (53 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (6 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (2 proteins)

6. Protein HIV-1 reverse transcriptase [56689] (2 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (90 PDB entries)

8. Domain d1rt3a2: 1rt3 A:2-429 [43052]
   Other proteins in same PDB: d1rt3a1
   complexed with u05; mutant

Details for d1rt3a2

PDB Entry: 1rt3, 3 Å

PDB Description: azt drug resistant hiv-1 reverse transcriptase complexed with 1051u91

PDB Compounds: (A:) hiv-1 reverse transcriptase

SCOP Domain Sequences for d1rt3a2:

Sequence, based on SEQRES records:

>d1rt3a2 e.8.1.2 (A:2-429) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
ispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvf
aikkknstrwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpld
edfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviy
qymddlyvgsdleigqhrtkieelrqhllrwglftpdqkhqkeppflwmgyelhpdkwtv
qpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeael
elaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgah
tndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpp
lvklwyql

Sequence, based on observed residues (ATOM records):

>d1rt3a2 e.8.1.2 (A:2-429) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
ispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvf
aikkknstrwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpld
edfrkytaftipsipgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymd
dlyvgsdleigqhrtkieelrqhllrwglftpdqkhqkeppflwmgyelhpdkwtvqpiv
lpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelae
nreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndv
kqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvkl
wyql

Timeline for d1rt3a2:

• d1rt3a2 first appeared (with stable ids) in SCOP 1.55
  
• d1rt3a2 appears in SCOP 1.71
  
• d1rt3a2 appears in SCOP 1.75
  
• d1rt3a2 appears in the current release, SCOPe 2.08