SCOPe 2.08: Domain d1rtdd_: 1rtd D:

Lineage for d1rtdd_ (1rtd D:)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (9 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (3 proteins)

6. Protein HIV-1 reverse transcriptase [56689] (4 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (206 PDB entries)
   Uniprot P04585 159-692 # chain A coverage; chain B is shorter: 162-582 ! Uniprot P03366 186-725 # chain A coverage; chain B coverage: 156-584 ! Uniprot P04585 158-698 # chain A coverage; chain B is shorter: 159-595

8. Domain d1rtdd_: 1rtd D: [43051]
   Other proteins in same PDB: d1rtda1, d1rtdc1
   protein/DNA complex; complexed with mg, ttp

Details for d1rtdd_

PDB Entry: 1rtd, 3.2 Å

PDB Description: structure of a catalytic complex of hiv-1 reverse transcriptase: implications for nucleoside analog drug resistance

PDB Compounds: (D:) protein (reverse transcriptase)

SCOPe Domain Sequences for d1rtdd_:

Sequence, based on SEQRES records:

>d1rtdd_ e.8.1.2 (D:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
spietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfa
ikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvplde
dfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyq
ymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvq
pivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaele
laenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgaht
ndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntppl
vklwyql

Sequence, based on observed residues (ATOM records):

>d1rtdd_ e.8.1.2 (D:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
spietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfa
ikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvplde
dfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyq
ymddlyvgsdleigqhrtkieelrqhllrwglttpgyelhpdkwtvqpivlpekdswtvn
diqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvh
gvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqki
ttesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyql

Timeline for d1rtdd_:

• d1rtdd_ first appeared (with stable ids) in SCOP 1.55, called d1rtdd1
  
• d1rtdd_ appears in SCOPe 2.07