SCOPe 2.05: Domain d1hara_: 1har A:

Lineage for d1hara_ (1har A:)

1. Root: SCOPe 2.05

2. Class e: Multi-domain proteins (alpha and beta) [56572] (68 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (3 proteins)

6. Protein HIV-1 reverse transcriptase [56689] (3 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (153 PDB entries)
   Uniprot P04585 159-692 # chain A coverage; chain B is shorter: 162-582 ! Uniprot P03366 186-725 # chain A coverage; chain B coverage: 156-584 ! Uniprot P04585 158-698 # chain A coverage; chain B is shorter: 159-595

8. Domain d1hara_: 1har A: [43025]
   fragment of "palm" and "fingers" domains

Details for d1hara_

PDB Entry: 1har, 2.2 Å

PDB Description: 2.2 angstroms resolution structure of the amino-terminal half of hiv-1 reverse transcriptase (fingers and palm subdomains)

PDB Compounds: (A:) hiv-1 reverse transcriptase (fingers and palm subdomains)

SCOPe Domain Sequences for d1hara_:

Sequence, based on SEQRES records:

>d1hara_ e.8.1.2 (A:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
pispietvpvklkpgmdgpkvaqwpltaakiaalvaictemekegkiskigpenpyntpv
faikkkdstkwaklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilapfkaanpdivi
yqymddlyvgsdlaigahrtkieelrqhllrwgltt

Sequence, based on observed residues (ATOM records):

>d1hara_ e.8.1.2 (A:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
pispietvpvklkpgmdgpkvaqwpltaakiaalvaictemekegkiskigpenpyntpv
faiwaklvdfrelnkrtqdfwevksvtvldvgdayfsvpldedfrkytaftipsinnetp
giryqynvlpqgwkgspaifqssmtkilapfkaanpdiviyqymddlyvgsdlaigahrt
kieelrqhllrwgltt

Timeline for d1hara_:

• d1hara_ first appeared (with stable ids) in SCOP 1.55, called d1har__
  
• d1hara_ appears in SCOPe 2.04
  
• d1hara_ appears in SCOPe 2.06
  
• d1hara_ appears in the current release, SCOPe 2.08