SCOPe 2.08: Domain d8grgb_: 8grg B:

Lineage for d8grgb_ (8grg B:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.0: automated matches [191423] (1 protein)
   not a true family

6. Protein automated matches [190603] (25 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [329721] (12 PDB entries)

8. Domain d8grgb_: 8grg B: [423522]
   automated match to d5grfb_
   mutant

Details for d8grgb_

PDB Entry: 8grg, 2.7 Å

PDB Description: crystal structure of a constitutively active mutant of the alpha gamma heterodimer of human idh3

PDB Compounds: (B:) Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

SCOPe Domain Sequences for d8grgb_:

Sequence, based on SEQRES records:

>d8grgb_ c.77.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
rhtvtmipgdgigpelmlhvksvfrhacvpvdfeevhvssnadeedirnaimairrnrva
lkgnietnhnlppshksrnnilrtsldlyanvihckslpgvvtrhkdidilivrentege
ysslehesvagvveslkiitkakslriaeyafklaqesgrkkvtavhkanimklgdglfl
qccrevaarypqitfenmivdnttmqlvsrpqqfdvmvmpnlygnivnnvcaglvggpgl
vaganyghvyavfetatrntgksianknianptatllascmmldhlklhsyatsirkavl
asmdnenmhtpdiggqgttseaiqdvirhirvingravea

Sequence, based on observed residues (ATOM records):

>d8grgb_ c.77.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
rhtvtmipgdgigpelmlhvksvfrhacvpvdfeevhedirnaimairrnrvalkgniek
srnnilrtsldlyanvihckslpgvvtrhkdidilivrenslehesvagvveslkiitka
kslriaeyafklaqesgrkkvtavhkanimklgdglflqccrevaarypqitfenmivdn
ttmqlvsrpqqfdvmvmpnlygnivnnvcaglvggpglvaganyghvyavfetatrntgk
sianknianptatllascmmldhlklhsyatsirkavlasmdnenmhtpdiggqgttsea
iqdvirhirvingravea

Timeline for d8grgb_:

• d8grgb_ is new in SCOPe 2.08-stable