SCOPe 2.08: Domain d7kp6a_: 7kp6 A:

Lineage for d7kp6a_ (7kp6 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Activated CDC42 kinase 1, ACK1 [111200] (1 species)
   PTK group; Tck subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [111201] (11 PDB entries)
   Uniprot Q07912 117-389

8. Domain d7kp6a_: 7kp6 A: [422374]
   automated match to d1u54a_
   complexed with cl, wtp

Details for d7kp6a_

PDB Entry: 7kp6, 1.79 Å

PDB Description: structure of ack1 kinase in complex with a selective inhibitor

PDB Compounds: (A:) Activated CDC42 kinase 1

SCOPe Domain Sequences for d7kp6a_:

Sequence, based on SEQRES records:

>d7kp6a_ d.144.1.7 (A:) Activated CDC42 kinase 1, ACK1 {Human (Homo sapiens) [TaxId: 9606]}
ltcligekdlrlleklgdgsfgvvrrgewdapsgktvsvavkclkpdvlsqpeamddfir
evnamhsldhrnlirlygvvltppmkmvtelaplgslldrlrkhqghfllgtlsryavqv
aegmgyleskrfihrdlaarnlllatrdlvkigdfglmralpqnddhyvmqehrkvpfaw
capeslktrtfshasdtwmfgvtlwemftygqepwiglngsqilhkidkegerlprpedc
pqdiynvmvqcwahkpedrptfvalrdflleaqpt

Sequence, based on observed residues (ATOM records):

>d7kp6a_ d.144.1.7 (A:) Activated CDC42 kinase 1, ACK1 {Human (Homo sapiens) [TaxId: 9606]}
ltcligekdlrlleklgdgsfgvvrrgewdapsgktvsvavkclpeamddfirevnamhs
ldhrnlirlygvvltppmkmvtelaplgslldrlrkhqghfllgtlsryavqvaegmgyl
eskrfihrdlaarnlllatrdlvkigdfglmralpqnddhyvmqehrkvpfawcapeslk
trtfshasdtwmfgvtlwemftygqepwiglngsqilhkidkegerlprpedcpqdiynv
mvqcwahkpedrptfvalrdflleaqpt

Timeline for d7kp6a_:

• d7kp6a_ is new in SCOPe 2.08-stable