SCOPe 2.05: Domain d1a41a_: 1a41 A:

Lineage for d1a41a_ (1a41 A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.163: DNA breaking-rejoining enzymes [56348] (1 superfamily)
   core: alpha3-beta3-alpha4; one side of beta-sheet is exposed

4. Superfamily d.163.1: DNA breaking-rejoining enzymes [56349] (2 families)

5. Family d.163.1.2: Eukaryotic DNA topoisomerase I, catalytic core [56361] (1 protein)

6. Protein Eukaryotic DNA topoisomerase I, catalytic core [56362] (2 species)

7. Species Vaccinia virus [TaxId:10245] [56364] (1 PDB entry)

8. Domain d1a41a_: 1a41 A: [42174]
   complexed with so4

Details for d1a41a_

PDB Entry: 1a41, 2.3 Å

PDB Description: type 1-topoisomerase catalytic fragment from vaccinia virus

PDB Compounds: (A:) topoisomerase I

SCOPe Domain Sequences for d1a41a_:

Sequence, based on SEQRES records:

>d1a41a_ d.163.1.2 (A:) Eukaryotic DNA topoisomerase I, catalytic core {Vaccinia virus [TaxId: 10245]}
nakrdrifvrvynvmkrincfinknikksstdsnyqlavfmlmetmffirfgkmkylken
etvglltlknkhieispdeivikfvgkdkvshefvvhksnrlykpllkltddsspeeflf
nklserkvyecikqfgirikdlrtygvnytflynfwtnvksisplpspkklialtikqta
evvghtpsiskraymattilemvkdknfldvvskttfdeflsivvdhvks

Sequence, based on observed residues (ATOM records):

>d1a41a_ d.163.1.2 (A:) Eukaryotic DNA topoisomerase I, catalytic core {Vaccinia virus [TaxId: 10245]}
nakrdrifvrvynvmkrincfinknikksstdsnyqlavfmlmetmffkenetvglltlk
nkhieispdeivikfvgkdkvshefvvhksnrlykpllkltddsspeeflfnklserkvy
ecikqfgirikdlrtygvnytflynfwtnvksisplpspkklialtikqtaevvghtpsi
skraymattilemvkdknfldvvskttfdeflsivvdhvks

Timeline for d1a41a_:

• d1a41a_ first appeared (with stable ids) in SCOP 1.55, called d1a41__
  
• d1a41a_ appears in SCOPe 2.04
  
• d1a41a_ appears in SCOPe 2.06
  
• d1a41a_ appears in the current release, SCOPe 2.08