SCOPe 2.02: Domain d1a35a1: 1a35 A:431-635,A:713-765

Lineage for d1a35a1 (1a35 A:431-635,A:713-765)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.163: DNA breaking-rejoining enzymes [56348] (1 superfamily)
   core: alpha3-beta3-alpha4; one side of beta-sheet is exposed

4. Superfamily d.163.1: DNA breaking-rejoining enzymes [56349] (2 families)

5. Family d.163.1.2: Eukaryotic DNA topoisomerase I, catalytic core [56361] (1 protein)

6. Protein Eukaryotic DNA topoisomerase I, catalytic core [56362] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56363] (15 PDB entries)
   Uniprot P11387 203-765 ! Uniprot P11387 203-767

8. Domain d1a35a1: 1a35 A:431-635,A:713-765 [42171]
   Other proteins in same PDB: d1a35a2
   protein/DNA complex

Details for d1a35a1

PDB Entry: 1a35, 2.5 Å

PDB Description: human topoisomerase i/dna complex

PDB Compounds: (A:) protein (DNA topoisomerase I)

SCOPe Domain Sequences for d1a35a1:

Sequence; same for both SEQRES and ATOM records:

>d1a35a1 d.163.1.2 (A:431-635,A:713-765) Eukaryotic DNA topoisomerase I, catalytic core {Human (Homo sapiens) [TaxId: 9606]}
pssrikgekdwqkyetarrlkkcvdkirnqyredwkskemkvrqravalyfidklalrag
nekeegetadtvgccslrvehinlhpeldgqeyvvefdflgkdsiryynkvpvekrvfkn
lqlfmenkqpeddlfdrlntgilnkhlqdlmegltakvfrtynasitlqqqlkeltapde
nipakilsynranravailcnhqraXqialgtsklnfldpritvawckkwgvpiekiynk
tqrekfawaidmadedyef

Timeline for d1a35a1:

• d1a35a1 first appeared (with stable ids) in SCOP 1.55
  
• d1a35a1 appears in SCOPe 2.01
  
• d1a35a1 appears in SCOPe 2.03
  
• d1a35a1 appears in the current release, SCOPe 2.08