SCOP 1.63: Domain d1a31a1: 1a31 A:431-626,A:720-765

Lineage for d1a31a1 (1a31 A:431-626,A:720-765)

1. Root: SCOP 1.63

2. Class d: Alpha and beta proteins (a+b) [53931] (224 folds)

3. Fold d.163: DNA breaking-rejoining enzymes [56348] (1 superfamily)
   core: alpha3-beta3-alpha4; one side of beta-sheet is exposed

4. Superfamily d.163.1: DNA breaking-rejoining enzymes [56349] (2 families)

5. Family d.163.1.2: Eukaryotic DNA topoisomerase I, catalytic core [56361] (1 protein)

6. Protein Eukaryotic DNA topoisomerase I, catalytic core [56362] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56363] (7 PDB entries)

8. Domain d1a31a1: 1a31 A:431-626,A:720-765 [42170]
   Other proteins in same PDB: d1a31a2
   protein/DNA complex; complexed with 5iu

Details for d1a31a1

PDB Entry: 1a31, 2.1 Å

PDB Description: human reconstituted dna topoisomerase i in covalent complex with a 22 base pair dna duplex

SCOP Domain Sequences for d1a31a1:

Sequence; same for both SEQRES and ATOM records:

>d1a31a1 d.163.1.2 (A:431-626,A:720-765) Eukaryotic DNA topoisomerase I, catalytic core {Human (Homo sapiens)}
pssrikgekdwqkyetarrlkkcvdkirnqyredwkskemkvrqravalyfidklalrag
nekeegetadtvgccslrvehinlhpeldgqeyvvefdflgkdsiryynkvpvekrvfkn
lqlfmenkqpeddlfdrlntgilnkhlqdlmegltakvfrtynasitlqqqlkeltapde
nipakilsynranravXklnyldpritvawckkwgvpiekiynktqrekfawaidmaded
yef

Timeline for d1a31a1:

• d1a31a1 first appeared (with stable ids) in SCOP 1.55
  
• d1a31a1 appears in SCOP 1.61
  
• d1a31a1 appears in SCOP 1.65
  
• d1a31a1 appears in the current release, SCOPe 2.08