SCOPe 2.08: Domain d7d8ec_: 7d8e C:

Lineage for d7d8ec_ (7d8e C:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.56: Phosphorylase/hydrolase-like [53162] (8 superfamilies)
   core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops

4. Superfamily c.56.5: Zn-dependent exopeptidases [53187] (10 families)
   core: mixed beta-sheet of 8 strands, order 12435867; strands 2, 6 & 7 are antiparallel to the rest

5. Family c.56.5.8: Glutaminyl-peptide cyclotransferase-like [142532] (1 protein)
   part of Pfam PF04389

6. Protein Glutaminyl-peptide cyclotransferase, QPCT [142533] (2 species)
   Glutaminyl cyclase

7. Species Human (Homo sapiens) [TaxId:9606] [142534] (29 PDB entries)
   Uniprot Q16769 33-361

8. Domain d7d8ec_: 7d8e C: [421215]
   automated match to d3pbea_
   complexed with edo, gyo, so4, zn; mutant

Details for d7d8ec_

PDB Entry: 7d8e, 2 Å

PDB Description: crystal structure of double mutant y115e y117e human secretory glutaminyl cyclase in complex with lsb-09

PDB Compounds: (C:) Glutaminyl-peptide cyclotransferase

SCOPe Domain Sequences for d7d8ec_:

Sequence, based on SEQRES records:

>d7d8ec_ c.56.5.8 (C:) Glutaminyl-peptide cyclotransferase, QPCT {Human (Homo sapiens) [TaxId: 9606]}
awpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhimqr
iqrlqadwvleidtflsqtpegersfsniistlnptakrhlvlachydskyfshwnnrvf
vgatdsavpcammlelaraldkkllslktvsdskpdlslqliffdgeeaflhwspqdsly
gsrhlaakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlqai
ehelhelgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtmdd
neenldestidnlnkilqvfvleylhl

Sequence, based on observed residues (ATOM records):

>d7d8ec_ c.56.5.8 (C:) Glutaminyl-peptide cyclotransferase, QPCT {Human (Homo sapiens) [TaxId: 9606]}
awpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhimqr
iqrlqadwvleidtflsqtpegersfsniistlnptakrhlvlachydskyfshnrvfvg
atdsavpcammlelaraldkkllslkdlslqliffdgeeaflhwspqdslygsrhlaakm
astphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlqaiehelhelgl
lkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtmddneenldest
idnlnkilqvfvleylhl

Timeline for d7d8ec_:

• d7d8ec_ is new in SCOPe 2.08-stable