Class c: Alpha and beta proteins (a/b) [51349] (148 folds) |
Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily) core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456 The nucleotide-binding modes of this and the next two folds/superfamilies are similar |
Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) |
Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins) also known as short-chain dehydrogenases and SDR family parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7 has additional subdomain(s) that are not in the common domain |
Protein Erythromycin synthase, eryAI, 1st ketoreductase module, C-terminal domain [418935] (1 species) protein contains tandem repeat of two SDR-like modules resembling a dimer commonly found in the family; only the second module retains the coenzyme-binding site |
Saccharopolyspora erythraea [TaxId:1836] [419373] (4 PDB entries) Uniprot Q5UNP6 |
Domain d2fr0a1: 2fr0 A:1657-1915 [133959] Other proteins in same PDB: d2fr0a2 complexed with ndp has additional insertions and/or extensions that are not grouped together |
Domain d2fr1a1: 2fr1 A:1657-1915 [133961] Other proteins in same PDB: d2fr1a2 automated match to d2fr0a1 complexed with ndp has additional insertions and/or extensions that are not grouped together |
Domain d6w7sa2: 6w7s A:1659-1914 [392915] Other proteins in same PDB: d6w7sa1, d6w7sl1, d6w7sl2 automated match to d2fr1a1 complexed with cl, mes |
Domain d6wh9a2: 6wh9 A:1664-1909 [392953] Other proteins in same PDB: d6wh9a1, d6wh9c1, d6wh9c2, d6wh9d1, d6wh9d3, d6wh9f1, d6wh9f2, d6wh9g1, d6wh9i1, d6wh9i2 automated match to d2fr1a1 complexed with so4 |
Domain d6wh9d2: 6wh9 D:1659-1910 [392960] Other proteins in same PDB: d6wh9a1, d6wh9c1, d6wh9c2, d6wh9d1, d6wh9d3, d6wh9f1, d6wh9f2, d6wh9g1, d6wh9i1, d6wh9i2 automated match to d2fr1a1 complexed with so4 |
Domain d6wh9g2: 6wh9 G:1662-1910 [392956] Other proteins in same PDB: d6wh9a1, d6wh9c1, d6wh9c2, d6wh9d1, d6wh9d3, d6wh9f1, d6wh9f2, d6wh9g1, d6wh9i1, d6wh9i2 automated match to d2fr1a1 complexed with so4 |
Timeline for Protein Erythromycin synthase, eryAI, 1st ketoreductase module, C-terminal domain from c.2.1.2: Tyrosine-dependent oxidoreductases: