SCOPe 2.08: Domain d7bkoa_: 7bko A:

Lineage for d7bkoa_ (7bko A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cell cycle checkpoint kinase chk1 [64404] (1 species)
   CaMK group; CAMKL subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [64405] (100 PDB entries)

8. Domain d7bkoa_: 7bko A: [417674]
   automated match to d2ydia_
   complexed with tvw

Details for d7bkoa_

PDB Entry: 7bko, 2.3 Å

PDB Description: crystal structure of chk1 complex with compound 9

PDB Compounds: (A:) Serine/threonine-protein kinase Chk1

SCOPe Domain Sequences for d7bkoa_:

Sequence, based on SEQRES records:

>d7bkoa_ d.144.1.7 (A:) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
edwdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicinkmlnhen
vvkfyghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigi
thrdikpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefha
epvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkil
venpsaritipdikkdrwynkplkk

Sequence, based on observed residues (ATOM records):

>d7bkoa_ d.144.1.7 (A:) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
edwdlvqtlgegaygevqlavnrvteeavavkivdmkrnikkeicinkmlnhenvvkfyg
hrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigithrdik
penlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefhaepvdvw
scgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilvenpsa
ritipdikkdrwynkplkk

Timeline for d7bkoa_:

• d7bkoa_ is new in SCOPe 2.08-stable