SCOP 1.75: Domain d1he8a4: 1he8 A:726-1084

Lineage for d1he8a4 (1he8 A:726-1084)

1. Root: SCOP 1.75

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain [56171] (1 protein)

6. Protein Phoshoinositide 3-kinase (PI3K), catalytic domain [56172] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56174] (3 PDB entries)

8. Domain d1he8a4: 1he8 A:726-1084 [41717]
   Other proteins in same PDB: d1he8a1, d1he8a2, d1he8a3, d1he8b_
   complexed with gnp, mg; mutant

Details for d1he8a4

PDB Entry: 1he8, 3 Å

PDB Description: ras g12v - pi 3-kinase gamma complex

PDB Compounds: (A:) phosphatidylinositol 3-kinase catalytic subunit, gamma isoform

SCOP Domain Sequences for d1he8a4:

Sequence, based on SEQRES records:

>d1he8a4 d.144.1.4 (A:726-1084) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrv
pydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlil
qilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkde
vlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidf
ghilgnyksflginkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtn
lliilfsmmlmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqf

Sequence, based on observed residues (ATOM records):

>d1he8a4 d.144.1.4 (A:726-1084) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslssqvisqlkqklenlqnsqlpesfrvpydpglk
agalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrime
siwetesldlcllpygcistgdkigmieivkdattiakiqqstfkdevlnhwlkekspte
ekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghervpfvltpdf
lfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtdieyirdaltvgkn
eedakkyfldqievcrdkgwtvqf

Timeline for d1he8a4:

• d1he8a4 first appeared (with stable ids) in SCOP 1.55
  
• d1he8a4 appears in SCOP 1.73
  
• d1he8a4 appears in SCOPe 2.01
  
• d1he8a4 appears in the current release, SCOPe 2.08