SCOPe 2.03: Domain d2fgia_: 2fgi A:

Lineage for d2fgia_ (2fgi A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Fibroblast growth factor receptor 1 [56158] (1 species)
   PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56159] (14 PDB entries)

8. Domain d2fgia_: 2fgi A: [41699]
   complexed with pd1

Details for d2fgia_

PDB Entry: 2fgi, 2.5 Å

PDB Description: crystal structure of the tyrosine kinase domain of fgf receptor 1 in complex with inhibitor pd173074

PDB Compounds: (A:) protein (fibroblast growth factor (fgf) receptor 1)

SCOPe Domain Sequences for d2fgia_:

Sequence, based on SEQRES records:

>d2fgia_ d.144.1.7 (A:) Fibroblast growth factor receptor 1 {Human (Homo sapiens) [TaxId: 9606]}
elpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksdatek
dlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppgley
synpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfg
lardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggspypg
vpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivalts

Sequence, based on observed residues (ATOM records):

>d2fgia_ d.144.1.7 (A:) Fibroblast growth factor receptor 1 {Human (Homo sapiens) [TaxId: 9606]}
elpedprwelprdrlvlgkplgqvvlaeaiglpnrvtkvavkmlksdatekdlsdlisem
emmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppqlsskdlvscayq
vargmeylaskkcihrdlaarnvlvtednvmkiadfgladihhidyykktngrlpvkwma
pealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllkeghrmdkpsnctne
lymmmrdcwhavpsqrptfkqlvedldrivalts

Timeline for d2fgia_:

• d2fgia_ first appeared (with stable ids) in SCOP 1.55
  
• d2fgia_ appears in SCOPe 2.02
  
• d2fgia_ appears in SCOPe 2.04
  
• d2fgia_ appears in the current release, SCOPe 2.08