SCOP 1.73: Domain d1wfca_: 1wfc A:

Lineage for d1wfca_ (1wfc A:)

1. Root: SCOP 1.73

2. Class d: Alpha and beta proteins (a+b) [53931] (334 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (61 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase p38 [56129] (2 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56130] (41 PDB entries)

8. Domain d1wfca_: 1wfc A: [41643]

Details for d1wfca_

PDB Entry: 1wfc, 2.3 Å

PDB Description: structure of apo, unphosphorylated, p38 mitogen activated protein kinase p38 (p38 map kinase) the mammalian homologue of the yeast hog1 protein

PDB Compounds: (A:) mitogen-activated protein kinase p38

SCOP Domain Sequences for d1wfca_:

Sequence, based on SEQRES records:

>d1wfca_ d.144.1.7 (A:) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
rptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsiih
akrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltd
dhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtgyva
trwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpga
ellkkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqala
hayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvpp

Sequence, based on observed residues (ATOM records):

>d1wfca_ d.144.1.7 (A:) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
rptfyrqeltiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsiihak
rtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddh
vqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildftddemtgyvatrwyrap
eimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaellkkis
sesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqalahayfaqy
hdpddepvadpydqsfesrdllidewksltydevisfvpp

Timeline for d1wfca_:

• d1wfca_ first appeared (with stable ids) in SCOP 1.55, called d1wfc__
  
• d1wfca_ was called d1wfc__ in SCOP 1.71
  
• d1wfca_ appears in SCOP 1.75
  
• d1wfca_ appears in the current release, SCOPe 2.07