SCOPe 2.08: Domain d6h50a1: 6h50 A:26-622

Lineage for d6h50a1 (6h50 A:26-622)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.82: Double-stranded beta-helix [51181] (7 superfamilies)
   one turn of helix is made by two pairs of antiparallel strands linked with short turns
   has appearance of a sandwich of distinct architecture and jelly-roll topology

4. Superfamily b.82.2: Clavaminate synthase-like [51197] (16 families)
   Iron and ketoglutarate-dependent enzymes; elaborated version of this common fold

5. Family b.82.2.14: Jumonji domain / Histone demethylase core [254153] (7 proteins)
   Jumonji domain; Pfam PF02375 (JmjN) and Pfam PF02373 (JmjC); relationship to FIH1 (b.82.2.6) described in PubMed 16983801
   Pfam PF02375 (JmjN) and Pfam PF02373 (JmjC); relationship to FIH1 (b.82.2.6) described in PubMed 16983801; some members include C-terminal helical subdomain (Pfam PF17811)

6. Protein KDM5B (JARID1B or PLU1) core [419085] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [419582] (14 PDB entries)

8. Domain d6h50a1: 6h50 A:26-622 [416045]
   Other proteins in same PDB: d6h50a2, d6h50a3
   automated match to d5a1fa1
   complexed with dms, edo, fo2, mn, po4, zn

Details for d6h50a1

PDB Entry: 6h50, 2.19 Å

PDB Description: crystal structure of human kdm5b in complex with compound 34a

PDB Compounds: (A:) Lysine-specific demethylase 5B,Lysine-specific demethylase 5B

SCOPe Domain Sequences for d6h50a1:

Sequence, based on SEQRES records:

>d6h50a1 b.82.2.14 (A:26-622) KDM5B (JARID1B or PLU1) core {Human (Homo sapiens) [TaxId: 9606]}
flpppecpvfepsweefadpfafihkirpiaeqtgickvrpppdwqppfacdvdklhftp
riqrlneleaqtrvklggggardytlrtfgemadafksdyfnmpvhmvptelvekefwrl
vstieedvtveygadiaskefgsgfpvrdgkiklspeeeeyldsgwnlnnmpvmeqsvla
hitadicgmklpwlyvgmcfssfcwhiedhwsysinylhwgepktwygvpgyaaeqlenv
mkklapelfvsqpdllhqlvtimnpntlmthevpvyrtnqcagefvitfprayhsgfnqg
fnfaeavnfctvdwlplgrqcvehyrllh

Sequence, based on observed residues (ATOM records):

>d6h50a1 b.82.2.14 (A:26-622) KDM5B (JARID1B or PLU1) core {Human (Homo sapiens) [TaxId: 9606]}
flpppecpvfepsweefadpfafihkirpiaeqtgickvrpppdwqppfacdvdklhftp
riqrlneleaqtrvkrdytlrtfgemadafksdyfnmpvhmvptelvekefwrlvstiee
dvtveygadiaskefgsgfpvrdgiklspeeeeyldsgwnlnnmpvmeqsvlahitadic
gmklpwlyvgmcfssfcwhiedhwsysinylhwgepktwygvpgyaaeqlenvmkklape
lfvsqpdllhqlvtimnpntlmthevpvyrtnqcagefvitfprayhsgfnqgfnfaeav
nfctvdwlplgrqcvehyrllh

Timeline for d6h50a1:

• d6h50a1 is new in SCOPe 2.08-stable