SCOP 1.71: Domain d1di8a_: 1di8 A:

Lineage for d1di8a_ (1di8 A:)

1. Root: SCOP 1.71

2. Class d: Alpha and beta proteins (a+b) [53931] (286 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (60 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (80 PDB entries)

8. Domain d1di8a_: 1di8 A: [41601]
   complexed with dtq

Details for d1di8a_

PDB Entry: 1di8, 2.2 Å

PDB Description: the structure of cyclin-dependent kinase 2 (cdk2) in complex with 4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline

SCOP Domain Sequences for d1di8a_:

Sequence, based on SEQRES records:

>d1di8a_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens)}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

Sequence, based on observed residues (ATOM records):

>d1di8a_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens)}
menfqkvekigegtygvvykarnkltgevvalkkirgvpstaireisllkelnhpnivkl
ldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvlhr
dlkpqnllintegaikladfglarafevvtlwyrapeillgckyystavdiwslgcifae
mvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwarqdfskvvppl
dedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

Timeline for d1di8a_:

• d1di8a_ first appeared (with stable ids) in SCOP 1.55
  
• d1di8a_ appears in SCOP 1.69
  
• d1di8a_ appears in SCOP 1.73
  
• d1di8a_ appears in the current release, SCOPe 2.08