SCOPe 2.02: Domain d1dm2a_: 1dm2 A:

Lineage for d1dm2a_ (1dm2 A:)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (223 PDB entries)
   Uniprot P24941

8. Domain d1dm2a_: 1dm2 A: [41598]
   complexed with edo, hmd

Details for d1dm2a_

PDB Entry: 1dm2, 2.1 Å

PDB Description: human cyclin-dependent kinase 2 complexed with the inhibitor hymenialdisine

PDB Compounds: (A:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d1dm2a_:

Sequence, based on SEQRES records:

>d1dm2a_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

Sequence, based on observed residues (ATOM records):

>d1dm2a_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkipstaireisllkelnhpnivklldv
ihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvlhrdlk
pqnllintegaikladfglvtlwyrapeillgckyystavdiwslgcifaemvtrralfp
gdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwarqdfskvvppldedgrslls
qmlhydpnkrisakaalahpffqdvtkpvphlrl

Timeline for d1dm2a_:

• d1dm2a_ first appeared (with stable ids) in SCOP 1.55
  
• d1dm2a_ appears in SCOPe 2.01
  
• d1dm2a_ appears in SCOPe 2.03
  
• d1dm2a_ appears in the current release, SCOPe 2.08