SCOPe 2.08: Domain d4o14b2: 4o14 B:164-487

Lineage for d4o14b2 (4o14 B:164-487)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.17: Nicotinate/Quinolinate PRTase C-terminal domain-like [51690] (3 families)
   incomplete beta/alpha barrel with parallel beta-sheet of 7 strands

5. Family c.1.17.2: Nicotinate phosphoribosyltransferase C-terminal domain-like [110910] (2 proteins)
   automatically mapped to Pfam PF04095

6. Protein automated matches [419237] (3 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [419806] (63 PDB entries)

8. Domain d4o14b2: 4o14 B:164-487 [414029]
   Other proteins in same PDB: d4o14a1, d4o14b1
   automated match to d2h3ba2
   complexed with edo, po4

Details for d4o14b2

PDB Entry: 4o14, 1.87 Å

PDB Description: Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors

PDB Compounds: (B:) Nicotinamide phosphoribosyltransferase

SCOPe Domain Sequences for d4o14b2:

Sequence, based on SEQRES records:

>d4o14b2 c.1.17.2 (B:164-487) automated matches {Human (Homo sapiens) [TaxId: 9606]}
nfreqkkilakylletsgnldgleyklhdfgyrgvssqetagigasahlvnfkgtdtvag
lalikkyygtkdpvpgysvpaaehstitawgkdhekdafehivtqfssvpvsvvsdsydi
ynacekiwgedlrhlivsrstqapliirpdsgnpldtvlkvleilgkkfpvtenskgykl
lppylrviqgdgvdintlqeivegmkqkmwsieniafgsgggllqkltrdllncsfkcsy
vvtnglginvfkdpvadpnkrskkgrlslhrtpagnfvtleegkgdleeygqdllhtvfk
ngkvtksysfdeirknaqlniele

Sequence, based on observed residues (ATOM records):

>d4o14b2 c.1.17.2 (B:164-487) automated matches {Human (Homo sapiens) [TaxId: 9606]}
nfreqkkilakylletsgnldgleyklhdfgyrgvssqetagigasahlvnfkgtdtvag
lalikkyygtkdpvpgysvpaaehstitawgkdhekdafehivtqfssvpvsvvsdsydi
ynacekiwgedlrhlivsrstqapliirpdsgnpldtvlkvleilgkkfpvtenskgykl
lppylrviqgdgvdintlqeivegmkqkmwsieniafgsggglkltrdllncsfkcsyvv
tnglginvfkdpvadpnkrskkgrlslhrtpagnfvtleegkgdleeygqdllhtvfkng
kvtksysfdeirknaqlniele

Timeline for d4o14b2:

• d4o14b2 is new in SCOPe 2.08-stable