SCOPe 2.08: Domain d4lwwb1: 4lww B:8-163

Lineage for d4lwwb1 (4lww B:8-163)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.41: alpha/beta-Hammerhead [54664] (5 superfamilies)
   core: beta-BETA-alpha-beta-BETA-beta-alpha; contains a beta-hammerhead motif similar to that in barrel-sandwich hybrids

4. Superfamily d.41.2: Nicotinate/Quinolinate PRTase N-terminal domain-like [54675] (4 families)

5. Family d.41.2.0: automated matches [227168] (1 protein)
   not a true family

6. Protein automated matches [226878] (11 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [419805] (63 PDB entries)

8. Domain d4lwwb1: 4lww B:8-163 [413957]
   Other proteins in same PDB: d4lwwa2, d4lwwb2
   automated match to d2h3ba1
   complexed with edo, lww, po4

Details for d4lwwb1

PDB Entry: 4lww, 1.64 Å

PDB Description: Discovery of Potent and Efficacious Cyanoguanidine-containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

PDB Compounds: (B:) Nicotinamide phosphoribosyltransferase

SCOPe Domain Sequences for d4lwwb1:

Sequence, based on SEQRES records:

>d4lwwb1 d.41.2.0 (B:8-163) automated matches {Human (Homo sapiens) [TaxId: 9606]}
efnillatdsykvthykqyppntskvysyfecrekktensklrkvkyeetvfyglqyiln
kylkgkvvtkekiqeakdvykehfqddvfnekgwnyilekydghlpieikavpegfvipr
gnvlftventdpecywltnwietilvqswypitvat

Sequence, based on observed residues (ATOM records):

>d4lwwb1 d.41.2.0 (B:8-163) automated matches {Human (Homo sapiens) [TaxId: 9606]}
efnillatdsykvthykqyppntskvysyfecrekvkyeetvfyglqyilnkylkgkvvt
kekiqeakdvykehfqddvfnekgwnyilekydghlpieikavpegfviprgnvlftven
tdpecywltnwietilvqswypitvat

Timeline for d4lwwb1:

• d4lwwb1 is new in SCOPe 2.08-stable