Lineage for d1hw3a_ (1hw3 A:)

  1. Root: SCOP 1.55
  2. 28523Class d: Alpha and beta proteins (a+b) [53931] (184 folds)
  3. 35325Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
  4. 35326Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (1 family) (S)
  5. 35327Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (3 proteins)
  6. 35339Protein Thymidylate synthase [55833] (7 species)
  7. 35414Species Human (Homo sapiens) [TaxId:9606] [55840] (3 PDB entries)
  8. 35419Domain d1hw3a_: 1hw3 A: [41053]

Details for d1hw3a_

PDB Entry: 1hw3 (more details), 2 Å

PDB Description: structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors

SCOP Domain Sequences for d1hw3a_:

Sequence, based on SEQRES records: (download)

>d1hw3a_ d.117.1.1 (A:) Thymidylate synthase {Human (Homo sapiens)}
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikme

Sequence, based on observed residues (ATOM records): (download)

>d1hw3a_ d.117.1.1 (A:) Thymidylate synthase {Human (Homo sapiens)}
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvgdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvidt
iktnpddrriimcawnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfni
asyalltymiahitglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkvek
iddfkaedfqiegynphptikme

SCOP Domain Coordinates for d1hw3a_:

Click to download the PDB-style file with coordinates for d1hw3a_.
(The format of our PDB-style files is described here.)

Timeline for d1hw3a_: