SCOPe 2.04: Domain d1tvwa_: 1tvw A:

Lineage for d1tvwa_ (1tvw A:)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein Thymidylate synthase [55833] (7 species)

7. Species Lactobacillus casei [TaxId:1582] [55835] (51 PDB entries)

8. Domain d1tvwa_: 1tvw A: [41013]
   complexed with cb3, ump; mutant

Details for d1tvwa_

PDB Entry: 1tvw, 2.5 Å

PDB Description: contributions of orientation and hydrogen bonding to catalysis in asn- 229 mutants of thymidylate synthase

PDB Compounds: (A:) Thymidylate synthase

SCOPe Domain Sequences for d1tvwa_:

Sequence; same for both SEQRES and ATOM records:

>d1tvwa_ d.117.1.1 (A:) Thymidylate synthase {Lactobacillus casei [TaxId: 1582]}
mleqpyldlakkvldeghfkpdrthtgtysifghqmrfdlskgfpllttkkvpfglikse
llwflhgdtnirfllqhrnhiwdewafekwvksdeyhgpdmtdfghrsqkdpefaavyhe
emakfddrvlhddafaakygdlglvygsqwrawhtskgdtidqlgdvieqikthpysrrl
ivsawnpedvptmalppchtlyqfyvndgklslqlyqrsadiflgvpfsiasyallthlv
ahecglevgefihtfgdahlyvnhldqikeqlsrtprpaptlqlnpdkhdifdfdmkdik
llnydpypaikapvav

Timeline for d1tvwa_:

• d1tvwa_ first appeared (with stable ids) in SCOP 1.55, called d1tvw__
  
• d1tvwa_ appears in SCOPe 2.03
  
• d1tvwa_ appears in SCOPe 2.05
  
• d1tvwa_ appears in the current release, SCOPe 2.08