SCOPe 2.08: Domain d6xafa_: 6xaf A:

Lineage for d6xafa_ (6xaf A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (27 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.0: automated matches [191323] (1 protein)
   not a true family

6. Protein automated matches [190123] (158 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [186862] (207 PDB entries)

8. Domain d6xafa_: 6xaf A: [407253]
   automated match to d3ea5a_
   complexed with gdp, mg

Details for d6xafa_

PDB Entry: 6xaf, 1.97 Å

PDB Description: 1.9a crystal structure of the gtpase domain of parkinson's disease- associated protein lrrk2 carrying r1398h

PDB Compounds: (A:) Leucine-rich repeat serine/threonine-protein kinase 2

SCOPe Domain Sequences for d6xafa_:

Sequence, based on SEQRES records:

>d6xafa_ c.37.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
mklmivgntgsgkttllqqlmktkksdlgmqsatvgidvkdwpiqirdkrkrdlvlnvwd
fagheefysthphfmtqralylavydlskgqaevdamkpwlfnikarassspvilvgthl
dvsdeaqraacmskitkellnkrgfpairdyhfvnateesdalaklrktiineslnfkir

Sequence, based on observed residues (ATOM records):

>d6xafa_ c.37.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
mklmivgntgsgkttllqqlmkqsatvgidvkdwpiqirdkrkrdlvlnvwdfagheefy
sthphfmtqralylavydlskgqaevdamkpwlfnikarassspvilvgthldvsdeaqr
aacmskitkellnkrgfpairdyhfvnateesdalaklrktiineslnfkir

Timeline for d6xafa_:

• d6xafa_ first appeared in SCOPe 2.07