Lineage for d1fbzb_ (1fbz B:)

  1. Root: SCOPe 2.07
  2. 2530962Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2571840Fold d.93: SH2-like [55549] (1 superfamily)
    3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flanked by two helices
  4. 2571841Superfamily d.93.1: SH2 domain [55550] (2 families) (S)
  5. 2571842Family d.93.1.1: SH2 domain [55551] (35 proteins)
    Pfam PF00017
  6. 2572140Protein p56-lck tyrosine kinase [55552] (1 species)
  7. 2572141Species Human (Homo sapiens) [TaxId:9606] [55553] (11 PDB entries)
  8. 2572154Domain d1fbzb_: 1fbz B: [40423]
    complexed with cc1

Details for d1fbzb_

PDB Entry: 1fbz (more details), 2.4 Å

PDB Description: Structure-based design of a novel, osteoclast-selective, nonpeptide Src SH2 inhibitor with in vivo anti-resorptive activity
PDB Compounds: (B:) Proto-oncogene tyrosine-protein kinase LCK

SCOPe Domain Sequences for d1fbzb_:

Sequence; same for both SEQRES and ATOM records: (download)

>d1fbzb_ d.93.1.1 (B:) p56-lck tyrosine kinase {Human (Homo sapiens) [TaxId: 9606]}
epepwffknlsrkdaerqllapgnthgsfliresestagsfclsvrdfdqnqgevvkhyk
irnldnggfyispritfpglhelvrhytnasdglctrlsrpcqt

SCOPe Domain Coordinates for d1fbzb_:

Click to download the PDB-style file with coordinates for d1fbzb_.
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Timeline for d1fbzb_: