SCOPe 2.08: Domain d6wvzm1: 6wvz M:40-515

Lineage for d6wvzm1 (6wvz M:40-515)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.69: 7-bladed beta-propeller [50964] (15 superfamilies)
   consists of seven 4-stranded beta-sheet motifs; meander

4. Superfamily b.69.12: Sema domain [101912] (1 family)
   irregular 7-bladed beta-propeller with a large insertion in the fifth blade
   automatically mapped to Pfam PF01403

5. Family b.69.12.1: Sema domain [101913] (3 proteins)
   Pfam PF01403

6. Protein Hepatocyte growth factor receptor [110292] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [110293] (2 PDB entries)
   Uniprot P08581 40-564

8. Domain d6wvzm1: 6wvz M:40-515 [404169]
   Other proteins in same PDB: d6wvzh_, d6wvzl1, d6wvzl2, d6wvzm2, d6wvzm3
   automated match to d1shyb1
   complexed with fmt, nag

Details for d6wvzm1

PDB Entry: 6wvz, 3.1 Å

PDB Description: crystal structure of anti-met fab arm of amivantamab in complex with human met

PDB Compounds: (M:) Hepatocyte growth factor receptor

SCOPe Domain Sequences for d6wvzm1:

Sequence, based on SEQRES records:

>d6wvzm1 b.69.12.1 (M:40-515) Hepatocyte growth factor receptor {Human (Homo sapiens) [TaxId: 9606]}
kyqlpnftaetpiqnvilhehhiflgatnyiyvlneedlqkvaeyktgpvlehpdcfpcq
dcsskanlsggvwkdninmalvvdtyyddqliscgsvnrgtcqrhvfphnhtadiqsevh
cifspqieepsqcpdcvvsalgakvlssvkdrfinffvgntinssyfpdhplhsisvrrl
ketkdgfmfltdqsyidvlpefrdsypikyvhafesnnfiyfltvqretldaqtfhtrii
rfcsinsglhsymempleciltekrkkrstkkevfnilqaayvskpgaqlarqigaslnd
dilfgvfaqskpdsaepmdrsamcafpikyvndffnkivnknnvrclqhfygpnhehcfn
rtllrnssgcearrdeyrtefttalqrvdlfmgqfsevlltsistfikgdltianlgtse
grfmqvvvsrsgpstphvnflldshpvspevivehtlnqngytlvitgkkitkipl

Sequence, based on observed residues (ATOM records):

>d6wvzm1 b.69.12.1 (M:40-515) Hepatocyte growth factor receptor {Human (Homo sapiens) [TaxId: 9606]}
kyqlpnftaetpiqnvilhehhiflgatnyiyvlneedlqkvaeyktgpvlehpdcfpcq
dcsskanlsggvwkdninmalvvdtyyddqliscgsvnrgtcqrhvfphnhtadiqsevh
cifspqieepsqcpdcvvsalgakvlssvkdrfinffvgntinssyfpdhplhsisvrrl
ketkdgfmfltdqsyidvlpefrdsypikyvhafesnnfiyfltvqretldaqtfhtrii
rfcsinsglhsymempleciltekkevfnilqaayvskpgaqlarqigaslnddilfgvf
aqskpdsaepmdrsamcafpikyvndffnkivnknnvrclqhfygpnhehcfnrtllrns
gcearrdeyrtefttalqrvdlfmgqfsevlltsistfikgdltianlgtsegrfmqvvv
srsgpstphvnflldshpvspevivehtlnqngytlvitgkkitkipl

Timeline for d6wvzm1:

• d6wvzm1 first appeared in SCOPe 2.07