SCOPe 2.08: Domain d7d5ua_: 7d5u A:

Lineage for d7d5ua_ (7d5u A:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.0: automated matches [191552] (1 protein)
   not a true family

6. Protein automated matches [190954] (13 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [193159] (15 PDB entries)

8. Domain d7d5ua_: 7d5u A: [401923]
   Other proteins in same PDB: d7d5ud_
   automated match to d3zkqa_
   complexed with gx6

Details for d7d5ua_

PDB Entry: 7d5u, 2.04 Å

PDB Description: bace2 xaperone complex with n-{3-[(9s)-7-amino-2,2-difluoro-9-(prop-1- yn-1-yl)-6-oxa-8-azaspiro[3.5]non-7-en-9-yl]-4-fluorophenyl}-5- cyanopyridine-2-carboxamide

PDB Compounds: (A:) Beta-secretase 2

SCOPe Domain Sequences for d7d5ua_:

Sequence, based on SEQRES records:

>d7d5ua_ b.50.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
flamvdnlqgdsgrgyylemligtppqklqilvdtgssnfavagtphsyidtyfdterss
tyrskgfdvtvkytqgswtgfvgedlvtipkgfntsflvniatifesenfflpgikwngi
lglayatlakpsssletffdslvtqanipnvfsmqmcgaglpvagsgtnggslvlggiep
slykgdiwytpikeewyyqieilkleiggqslnldcreynadkaivdsgttllrlpqkvf
davveavaraslipefsdgfwtgsqlacwtnsetpwsyfpkisiylrdenssrsfritil
pqlyiqpmmgaglnyecyrfgispstnalvigatvmegfyvifdraqkrvgfaaspcaei
agaavseisgpfstedvasncvp

Sequence, based on observed residues (ATOM records):

>d7d5ua_ b.50.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
flamvdnlqgdsgrgyylemligtppqklqilvdtgssnfavagtphsyidtyfdterss
tyrskgfdvtvkytqgswtgfvgedlvtipkgfntsflvniatifesenfflpgikwngi
lglayatlakpsssletffdslvtqanipnvfsmqmcganggslvlggiepslykgdiwy
tpikeewyyqieilkleiggqslnldcreynadkaivdsgttllrlpqkvfdavveavar
aslipefsdgfwtgsqlacwtnsetpwsyfpkisiylrdenssrsfritilpqlyiqpml
nyecyrfgispstnalvigatvmegfyvifdraqkrvgfaaspcaeiagaavseisgpfs
tedvasncvp

Timeline for d7d5ua_:

• d7d5ua_ first appeared in SCOPe 2.07