SCOPe 2.08: Domain d7ackc1: 7ack C:1-294

Lineage for d7ackc1 (7ack C:1-294)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (417 PDB entries)
   Uniprot P24941

8. Domain d7ackc1: 7ack C:1-294 [401722]
   Other proteins in same PDB: d7acka2, d7ackb1, d7ackb2, d7ackc2, d7ackd1, d7ackd2
   automated match to d1gy3a_
   complexed with edo, na, no3, r7b

Details for d7ackc1

PDB Entry: 7ack, 1.8 Å

PDB Description: cdk2/cyclin a2 in complex with an imidazo[1,2-c]pyrimidin-5-one inhibitor

PDB Compounds: (C:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d7ackc1:

Sequence; same for both SEQRES and ATOM records:

>d7ackc1 d.144.1.7 (C:1-294) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvp

Timeline for d7ackc1:

• d7ackc1 first appeared in SCOPe 2.07