SCOPe 2.08: Domain d6w10b1: 6w10 B:1-234

Lineage for d6w10b1 (6w10 B:1-234)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.55: Ribonuclease H-like motif [53066] (7 superfamilies)
   3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145; strand 2 is antiparallel to the rest

4. Superfamily c.55.3: Ribonuclease H-like [53098] (18 families)
   consists of one domain of this fold

5. Family c.55.3.5: DnaQ-like 3'-5' exonuclease [53118] (17 proteins)
   contains Pfam PF00929

6. Protein Three prime repair exonuclease 1, TREX1 [159631] (1 species)

7. Species Mouse (Mus musculus) [TaxId:10090] [159632] (7 PDB entries)
   Uniprot Q91XB0 5-234! Uniprot Q91XB0 9-234

8. Domain d6w10b1: 6w10 B:1-234 [401625]
   Other proteins in same PDB: d6w10b2
   automated match to d3mxjb_
   mutant

Details for d6w10b1

PDB Entry: 6w10, 1.8 Å

PDB Description: structure of mouse trex1 with e198k disease-associated mutation

PDB Compounds: (B:) Three-prime repair exonuclease 1

SCOPe Domain Sequences for d6w10b1:

Sequence, based on SEQRES records:

>d6w10b1 c.55.3.5 (B:1-234) Three prime repair exonuclease 1, TREX1 {Mouse (Mus musculus) [TaxId: 10090]}
mgsqtlphghmqtlifldleatglpssrpevtelcllavhrralentsisqghpppvprp
prvvdklslciapgkacspgaseitglskaelevqgrqrfddnlaillraflqrqpqpcc
lvahngdrydfpllqtelarlstpspldgtfcvdsiaalkaleqasspsgngsrksyslg
siytrlywqaptdshtakgdvltllsicqwkpqallqwvdeharpfstvkpmyg

Sequence, based on observed residues (ATOM records):

>d6w10b1 c.55.3.5 (B:1-234) Three prime repair exonuclease 1, TREX1 {Mouse (Mus musculus) [TaxId: 10090]}
mgsqtlphghmqtlifldleatglpssrpevtelcllavhrralepppvprpprvvdkls
lciapgkacslskaelevqgrqrfddnlaillraflqrqpqpcclvahngdrydfpllqt
elarlstpspldgtfcvdsiaalkaleqksyslgsiytrlywqaptdshtakgdvltlls
icqwkpqallqwvdeharpfstvkpmyg

Timeline for d6w10b1:

• d6w10b1 first appeared in SCOPe 2.07