SCOPe 2.08: Domain d7b9lb_: 7b9l B:

Lineage for d7b9lb_ (7b9l B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Dual specificity mitogen-activated protein kinase kinase 1, Mek1 [118137] (2 species)
   OPK group (?); MAPKK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [118138] (36 PDB entries)
   Uniprot Q02750 61-381

8. Domain d7b9lb_: 7b9l B: [398457]
   automated match to d5hzea_
   complexed with anp, gol, mg, so4, t4n

Details for d7b9lb_

PDB Entry: 7b9l, 1.7 Å

PDB Description: mek1 in complex with compound 23

PDB Compounds: (B:) Dual specificity mitogen-activated protein kinase kinase 1,Dual specificity mitogen-activated protein kinase kinase 1

SCOPe Domain Sequences for d7b9lb_:

Sequence, based on SEQRES records:

>d7b9lb_ d.144.1.7 (B:) Dual specificity mitogen-activated protein kinase kinase 1, Mek1 {Human (Homo sapiens) [TaxId: 9606]}
eldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarklih
leikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagr
ipeqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsma
nsfvgtrsymsperlqgthysvqsdiwsmglslvemavgrypigsgsgsmaifelldyiv
nepppklpsgvfslefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcst
igl

Sequence, based on observed residues (ATOM records):

>d7b9lb_ d.144.1.7 (B:) Dual specificity mitogen-activated protein kinase kinase 1, Mek1 {Human (Homo sapiens) [TaxId: 9606]}
eldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarklih
leikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagr
ipeqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsma
rsymsperlqgthysvqsdiwsmglslvemavgrypigsgssmaifelldyivnepppkl
psgvfslefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstigl

Timeline for d7b9lb_:

• d7b9lb_ first appeared in SCOPe 2.07