SCOPe 2.08: Domain d7aqfa_: 7aqf A:

Lineage for d7aqfa_ (7aqf A:)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.1: Serpins [56573] (1 superfamily)
   contains a cluster of helices and a beta-sandwich

4. Superfamily e.1.1: Serpins [56574] (2 families)

5. Family e.1.1.1: Serpins [56575] (17 proteins)
   automatically mapped to Pfam PF00079

6. Protein Plasminogen activator inhibitor-1 [56587] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56588] (21 PDB entries)

8. Domain d7aqfa_: 7aqf A: [398432]
   automated match to d1lj5a_
   complexed with rv2

Details for d7aqfa_

PDB Entry: 7aqf, 1.77 Å

PDB Description: crystal structure of small molecule inhibitor tm5484 bound to stabilized active plasminogen activator inhibitor-1 (pai-1-stab)

PDB Compounds: (A:) Plasminogen activator inhibitor 1

SCOPe Domain Sequences for d7aqfa_:

Sequence, based on SEQRES records:

>d7aqfa_ e.1.1.1 (A:) Plasminogen activator inhibitor-1 {Human (Homo sapiens) [TaxId: 9606]}
hhppsyvahlasdfgvrvfqqvaqaskdrnvvfspygvasvlamlqlttggetqqqiqaa
mgfkiddkgmapalrhlykelmgpwnkdeisttdaifvqrdlklvqgfmphffrlfrstv
kqvdfseverarfiindwvkthtkgmishllgtgavdqltrlvlvnalyfngqwktpfpd
ssthrrlfhksdgstvsvpmmaqtnkfnytefttpdghyydilelpyhgdtlsmfiaapy
ekevplsaltnilsaqlishwkgnmtrlprllvlpkfsletevdlrkplenlgmtdmfrp
fqadftslsdqeplhvalalqkvkievnesgtvassstavivsarmapeeiiidrpflfv
vrhnptgtvlfmgqvmep

Sequence, based on observed residues (ATOM records):

>d7aqfa_ e.1.1.1 (A:) Plasminogen activator inhibitor-1 {Human (Homo sapiens) [TaxId: 9606]}
hhppsyvahlasdfgvrvfqqvaqaskdrnvvfspygvasvlamlqlttggetqqqiqaa
mgfkiddkgmapalrhlykelmgpwnkdeisttdaifvqrdlklvqgfmphffrlfrstv
kqvdfseverarfiindwvkthtkgmishllgtgavdqltrlvlvnalyfngqwktpfpd
ssthrrlfhksdgstvsvpmmaqtnkfnytefttpdghyydilelpyhgdtlsmfiaapy
ekevplsaltnilsaqlishwkgnmtrlprllvlpkfsletevdlrkplenlgmtdmfrp
fqadftslsdqeplhvalalqkvkievnesgtvataviapeeiiidrpflfvvrhnptgt
vlfmgqvmep

Timeline for d7aqfa_:

• d7aqfa_ first appeared in SCOPe 2.07