SCOPe 2.07: Domain d7aqga_: 7aqg A:

Lineage for d7aqga_ (7aqg A:)

1. Root: SCOPe 2.07

2. Class e: Multi-domain proteins (alpha and beta) [56572] (71 folds)

3. Fold e.1: Serpins [56573] (1 superfamily)
   contains a cluster of helices and a beta-sandwich

4. Superfamily e.1.1: Serpins [56574] (2 families)

5. Family e.1.1.1: Serpins [56575] (17 proteins)
   automatically mapped to Pfam PF00079

6. Protein Plasminogen activator inhibitor-1 [56587] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56588] (21 PDB entries)

8. Domain d7aqga_: 7aqg A: [398311]
   Other proteins in same PDB: d7aqgb_, d7aqgc_
   automated match to d1lj5a_
   complexed with rv2

Details for d7aqga_

PDB Entry: 7aqg, 2.27 Å

PDB Description: crystal structure of small molecule inhibitor tm5484 bound to stabilized active plasminogen activator inhibitor-1 (pai-1-w175f)

PDB Compounds: (A:) Plasminogen activator inhibitor 1

SCOPe Domain Sequences for d7aqga_:

Sequence, based on SEQRES records:

>d7aqga_ e.1.1.1 (A:) Plasminogen activator inhibitor-1 {Human (Homo sapiens) [TaxId: 9606]}
ppsyvahlasdfgvrvfqqvaqaskdrnvvfspygvasvlamlqlttggetqqqiqaamg
fkiddkgmapalrhlykelmgpwnkdeisttdaifvqrdlklvqgfmphffrlfrstvkq
vdfseverarfiindwvkthtkgmisnllgkgavdqltrlvlvnalyfngqfktpfpdss
thrrlfhksdgstvsvpmmaqtnkfnytefttpdghyydilelpyhgdtlsmfiaapyek
evplsaltnilsaqlishwkgnmtrlprllvlpkfsletevdlrkplenlgmtdmfrqfq
adftslsdqeplhvaqalqkvkievnesgtvassstavivsarmapeeiimdrpflfvvr
hnptgtvlfmgqvmep

Sequence, based on observed residues (ATOM records):

>d7aqga_ e.1.1.1 (A:) Plasminogen activator inhibitor-1 {Human (Homo sapiens) [TaxId: 9606]}
ppsyvahlasdfgvrvfqqvaqaskdrnvvfspygvasvlamlqlttggetqqqiqaamg
fkiddkgmapalrhlykelmgpwnkdeisttdaifvqrdlklvqgfmphffrlfrstvkq
vdfseverarfiindwvkthtkgmisnllgkgavdqltrlvlvnalyfngqfktpfpdss
thrrlfhksdgstvsvpmmaqtnkfnytefttpdghyydilelpyhgdtlsmfiaapyek
evplsaltnilsaqlishwkgnmtrlprllvlpkfsletevdlrkplenlgmtdmfrqfq
adftslsdqeplhvaqalqkvkievnesgtvpeeiimdrpflfvvrhnptgtvlfmgqvm
ep

Timeline for d7aqga_:

• d7aqga_ is new in SCOPe 2.07-stable
  
• d7aqga_ appears in the current release, SCOPe 2.08