SCOPe 2.08: Domain d7b3wa_: 7b3w A:

Lineage for d7b3wa_ (7b3w A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Hepatocyte growth factor receptor, c-MET [103300] (1 species)
   PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103301] (67 PDB entries)

8. Domain d7b3wa_: 7b3w A: [394386]
   automated match to d2g15a_
   complexed with edo, svh

Details for d7b3wa_

PDB Entry: 7b3w, 2.02 Å

PDB Description: crystal structure of c-met bound by compound 4

PDB Compounds: (A:) Hepatocyte growth factor receptor

SCOPe Domain Sequences for d7b3wa_:

Sequence, based on SEQRES records:

>d7b3wa_ d.144.1.7 (A:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
qhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihcavkslnritdigevsqflt
egiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirnethnptvkdligfgl
qvakgmkylaskkfvhrdlaarncmldekftvkvadfglardmydkeyysvhnktgaklp
vkwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfditvyllqgrrllqpe
ycpdplyevmlkcwhpkaemrpsfselvsrisaifstf

Sequence, based on observed residues (ATOM records):

>d7b3wa_ d.144.1.7 (A:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
qhvvigpsslivhfnevigrghfgcvyhgtlldgkkihcavkslnriimkdfshpnvlsl
lgiclrsplvvlpymkhgdlrnfirnethnptvkdligfglqvakgmkylaskkfvhrdl
aarncmldekftvkvadfglardmydkeyysvhnktgaklpvkwmaleslqtqkfttksd
vwsfgvllwelmtrgappypdvntfditvyllqgrrllqpeycpdplyevmlkcwhpkae
mrpsfselvsrisaifstf

Timeline for d7b3wa_:

• d7b3wa_ first appeared in SCOPe 2.07