SCOPe 2.08: Domain d6wh9g2: 6wh9 G:1662-1910

Lineage for d6wh9g2 (6wh9 G:1662-1910)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
   has additional subdomain(s) that are not in the common domain
   

6. Protein Erythromycin synthase, eryAI, 1st ketoreductase module, C-terminal domain [418935] (1 species)
   protein contains tandem repeat of two SDR-like modules resembling a dimer commonly found in the family; only the second module retains the coenzyme-binding site

7. Species Saccharopolyspora erythraea [TaxId:1836] [419373] (4 PDB entries)
   Uniprot Q5UNP6

8. Domain d6wh9g2: 6wh9 G:1662-1910 [392956]
   Other proteins in same PDB: d6wh9a1, d6wh9c1, d6wh9c2, d6wh9d1, d6wh9d3, d6wh9f1, d6wh9f2, d6wh9g1, d6wh9i1, d6wh9i2
   automated match to d2fr1a1
   complexed with so4

Details for d6wh9g2

PDB Entry: 6wh9, 2.75 Å

PDB Description: ketoreductase from module 1 of the 6-deoxyerythronolide b synthase (kr1) in complex with antibody fragment (fab) 1d10

PDB Compounds: (G:) kr1

SCOPe Domain Sequences for d6wh9g2:

Sequence, based on SEQRES records:

>d6wh9g2 c.2.1.2 (G:1662-1910) Erythromycin synthase, eryAI, 1st ketoreductase module, C-terminal domain {Saccharopolyspora erythraea [TaxId: 1836]}
wkptgtvlvtggtggvggqiarwlarrgaphlllvsrsgpdadgagelvaelealgartt
vaacdvtdresvrellggigddvplsavfhaaatlddgtvdtltgerierasrakvlgar
nlheltreldltafvlfssfasafgapglggyapgnayldglaqqrrsdglpatavawgt
wagsgmaegpvadrfrrhgviemppetacralqnaldraevcpividvrwdrfllaytaq
rptrlfdei

Sequence, based on observed residues (ATOM records):

>d6wh9g2 c.2.1.2 (G:1662-1910) Erythromycin synthase, eryAI, 1st ketoreductase module, C-terminal domain {Saccharopolyspora erythraea [TaxId: 1836]}
wkptgtvlvtggtggvggqiarwlarrgaphlllvsrsgpdadgagelvaelealgartt
vaacdvtdresvrellggigddvplsavfhaaatlddgtvdtltgerierasrakvlgar
nlheltreldltafvlfssfasafgapglggyapgnayldglaqqrrsdglpatavawgt
wagdrfrrhgviemppetacralqnaldraevcpividvrwdrfllaytaqrptrlfdei

Timeline for d6wh9g2:

• d6wh9g2 first appeared in SCOPe 2.07