SCOPe 2.08: Domain d6oqoa_: 6oqo A:

Lineage for d6oqoa_ (6oqo A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK6 [88859] (1 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88860] (16 PDB entries)

8. Domain d6oqoa_: 6oqo A: [391142]
   automated match to d2f2cb_
   complexed with n1j

Details for d6oqoa_

PDB Entry: 6oqo, 1.98 Å

PDB Description: cdk6 in complex with cpd24 n-(5-(6-ethyl-2,6-diazaspiro[3.3]heptan-2- yl)pyridin-2-yl)-5-fluoro-4-(4-methyl-5,6,7,8-tetrahydro-4h- pyrazolo[1,5-a]azepin-3-yl)pyrimidin-2-amine

PDB Compounds: (A:) cyclin-dependent kinase 6

SCOPe Domain Sequences for d6oqoa_:

Sequence, based on SEQRES records:

>d6oqoa_ d.144.1.7 (A:) Cyclin-dependent PK, CDK6 {Human (Homo sapiens) [TaxId: 9606]}
qqyecvaeigegaygkvfkardlknggrfvalkrvrvqtgeegmplstirevavlrhlet
fehpnvvrlfdvctvsrtdretkltlvfehvdqdlttyldkvpepgvptetikdmmfqll
rgldflhshrvvhrdlkpqnilvtssgqikladfglariysfqmaltsvvvtlwyrapev
llqssyatpvdlwsvgcifaemfrrkplfrgssdvdqlgkildviglpgeedwprdvalp
rqafhsksaqpiekfvtdidelgkdlllkcltfnpakrisaysalshpyfq

Sequence, based on observed residues (ATOM records):

>d6oqoa_ d.144.1.7 (A:) Cyclin-dependent PK, CDK6 {Human (Homo sapiens) [TaxId: 9606]}
qqyecvaeigegaygkvfkardlknggrfvalkrvrvqtggmplstirevavlrhletfe
hpnvvrlfdvctvkltlvfehvdqdlttyldkvpepgvptetikdmmfqllrgldflhsh
rvvhrdlkpqnilvtssgqikladfglavtlwyrapevllqssyatpvdlwsvgcifaem
frrkplfrgssdvdqlgkildviglpgeedwprdvalprqafhsksaqpiekfvtdidel
gkdlllkcltfnpakrisaysalshpyfq

Timeline for d6oqoa_:

• d6oqoa_ first appeared in SCOPe 2.07