SCOPe 2.07: Domain d6liob2: 6lio B:178-384

Lineage for d6liob2 (6lio B:178-384)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
   8-stranded mixed beta-sheet; 2 layers: alpha/beta

4. Superfamily d.122.1: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (5 families)

5. Family d.122.1.4: alpha-ketoacid dehydrogenase kinase, C-terminal domain [69804] (3 proteins)

6. Protein Pyruvate dehydrogenase kinase [69807] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [160702] (19 PDB entries)
   Uniprot Q15120 177-301

8. Domain d6liob2: 6lio B:178-384 [390899]
   Other proteins in same PDB: d6lioa1, d6liob1, d6liob3
   automated match to d2pnrb2
   complexed with eh3, gol, so4

Details for d6liob2

PDB Entry: 6lio, 1.76 Å

PDB Description: crystal structure of human pdk2 complexed with gm67520

PDB Compounds: (B:) [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial

SCOPe Domain Sequences for d6liob2:

Sequence, based on SEQRES records:

>d6liob2 d.122.1.4 (B:178-384) Pyruvate dehydrogenase kinase {Human (Homo sapiens) [TaxId: 9606]}
gstnpahpkhigsidpncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpih
mvyvpshlyhmlfelfknamratveshesslilppikvmvalgeedlsikmsdrgggvpl
rkierlfsymystaptpqpgtggtplagfgyglpisrlyakyfqgdlqlfsmegfgtdav
iylkalstdsverlpvynksawrhyqt

Sequence, based on observed residues (ATOM records):

>d6liob2 d.122.1.4 (B:178-384) Pyruvate dehydrogenase kinase {Human (Homo sapiens) [TaxId: 9606]}
gstnpahpkhigsidpncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpih
mvyvpshlyhmlfelfknamratveshesslilppikvmvalgeedlsikmsdrgggvpl
rkierlfsymysttplagfgyglpisrlyakyfqgdlqlfsmegfgtdaviylkalstds
verlpvynksawrhyqt

Timeline for d6liob2:

• d6liob2 is new in SCOPe 2.07-stable
  
• d6liob2 appears in the current release, SCOPe 2.08