SCOPe 2.08: Domain d7cvnc_: 7cvn C:

Lineage for d7cvnc_ (7cvn C:)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.7: Carbohydrate phosphatase [56654] (1 superfamily)
   N-terminal domain is an alpha+beta, C-terminal domain is an alpha/beta with mixed beta-sheet

4. Superfamily e.7.1: Carbohydrate phosphatase [56655] (3 families)

5. Family e.7.1.1: Inositol monophosphatase/fructose-1,6-bisphosphatase-like [56656] (7 proteins)

6. Protein Fructose-1,6-bisphosphatase [56657] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56659] (9 PDB entries)

8. Domain d7cvnc_: 7cvn C: [390058]
   automated match to d1rdza_
   complexed with fbp, gjo

Details for d7cvnc_

PDB Entry: 7cvn, 2.75 Å

PDB Description: the n-arylsulfonyl-indole-2-carboxamide-based inhibitors against fructose-1,6-bisphosphatase

PDB Compounds: (C:) Fructose-1,6-bisphosphatase 1

SCOPe Domain Sequences for d7cvnc_:

Sequence, based on SEQRES records:

>d7cvnc_ e.7.1.1 (C:) Fructose-1,6-bisphosphatase {Human (Homo sapiens) [TaxId: 9606]}
dvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygiagstnvtgd
qvkkldvlsndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidc
lvsvgtifgiyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldp
aigefilvdkdvkikkkgkiyslnegyardfdpavteyiqrkkfppdnsapygaryvgsm
vadvhrtlvyggiflypankkspngklrllyecnpmayvmekaggmattgkeavldvipt
dihqrapvilgspddvleflkvyekhsa

Sequence, based on observed residues (ATOM records):

>d7cvnc_ e.7.1.1 (C:) Fructose-1,6-bisphosphatase {Human (Homo sapiens) [TaxId: 9606]}
dvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygiagstqvkkl
dvlsndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidclvsvg
tifgiyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldpaigef
ilvdkdvkikkkgkiyslnegyardfdpavteyiqrkkfppdnsapygaryvgsmvadvh
rtlvyggiflypankkspngklrllyecnpmayvmekaggmattgkeavldviptdihqr
apvilgspddvleflkvyekhsa

Timeline for d7cvnc_:

• d7cvnc_ first appeared in SCOPe 2.07