SCOPe 2.08: Domain d6xvwa1: 6xvw A:663-796

Lineage for d6xvwa1 (6xvw A:663-796)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.41: Domain of poly(ADP-ribose) polymerase [47586] (1 superfamily)
   core: 4 helices: bundle; unusual topology

4. Superfamily a.41.1: Domain of poly(ADP-ribose) polymerase [47587] (2 families)
   duplication: consists of 2 helix-loop-helix structural repeats
   automatically mapped to Pfam PF02877

5. Family a.41.1.0: automated matches [227223] (1 protein)
   not a true family

6. Protein automated matches [226964] (2 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [225405] (61 PDB entries)

8. Domain d6xvwa1: 6xvw A:663-796 [387107]
   Other proteins in same PDB: d6xvwa2, d6xvwa3, d6xvwb2, d6xvwb3
   automated match to d4hhyd1
   protein/DNA complex; complexed with edo, ni, o3h

Details for d6xvwa1

PDB Entry: 6xvw, 2 Å

PDB Description: catalytic domain of human parp-1 in complex with the inhibitor mc2050

PDB Compounds: (A:) Poly [ADP-ribose] polymerase 1

SCOPe Domain Sequences for d6xvwa1:

Sequence, based on SEQRES records:

>d6xvwa1 a.41.1.0 (A:663-796) automated matches {Human (Homo sapiens) [TaxId: 9606]}
sklpkpvqdlikmifdvesmkkamveyeidlqkmplgklskrqiqaaysilsevqqavsq
gssdsqildlsnrfytliphdfgmkkppllnnadsvqakvemldnlldievaysllrggs
ddsskdpidvnyek

Sequence, based on observed residues (ATOM records):

>d6xvwa1 a.41.1.0 (A:663-796) automated matches {Human (Homo sapiens) [TaxId: 9606]}
sklpkpvqdlikmifdvesmkkamveyeidlqkmplgklskrqiqaaysilsevqqavsq
gssdsqildlsnrfytliphdfgppllnnadsvqakvemldnlldievaysllrgdsskd
pidvnyek

Timeline for d6xvwa1:

• d6xvwa1 first appeared in SCOPe 2.07