SCOPe 2.08: Domain d6p4ba2: 6p4b A:109-213

Lineage for d6p4ba2 (6p4b A:109-213)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (4 species)

7. Species Mouse (Mus musculus) [TaxId:10090] [88567] (374 PDB entries)
   Uniprot P01837# KAC_MOUSE Ig kappa chain C region; 99% sequence identity ! SQ NA # natural chimera; best hits are: Uniprot P01637 (Ig kappa chain V-V region T1) and Uniprot P01837 (Ig kappa chain C region) ! Uniprot P01837 # KAC_MOUSE Ig kappa chain C region ! Uniprot P01837 # KAC_MOUSE (P01837) Ig kappa chain C region ! SQ NA # part of Fab 28 against HIV-1 RT ! Uniprot P01837 # ! KAC_MOUSE Ig kappa chain C region

8. Domain d6p4ba2: 6p4b A:109-213 [386262]
   Other proteins in same PDB: d6p4ba1, d6p4bb_, d6p4bc_, d6p4bd_, d6p4bh_, d6p4bl1
   automated match to d3hfml2
   complexed with cl; mutant

Details for d6p4ba2

PDB Entry: 6p4b, 1.9 Å

PDB Description: hyhel10 fab variant hyhel10-4x (heavy chain mutations l4f, y33h, s56n, and y58f) bound to hen egg lysozyme variant hel2x-flex (mutations r21q, r73e, c76s, and c94s)

PDB Compounds: (A:) HyHEL10 Fab light chain

SCOPe Domain Sequences for d6p4ba2:

Sequence, based on SEQRES records:

>d6p4ba2 b.1.1.2 (A:109-213) Immunoglobulin light chain kappa constant domain, CL-kappa {Mouse (Mus musculus) [TaxId: 10090]}
adaaptvsifppsseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqds
kdstysmsstltltkdeyerhnsytceathktstspivksfnrne

Sequence, based on observed residues (ATOM records):

>d6p4ba2 b.1.1.2 (A:109-213) Immunoglobulin light chain kappa constant domain, CL-kappa {Mouse (Mus musculus) [TaxId: 10090]}
adaaptvsifppsseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqds
kdstysmsstltltkdeyerhnsytceathspivksfnrne

Timeline for d6p4ba2:

• d6p4ba2 first appeared in SCOPe 2.07