SCOP 1.71: Domain d1qr1d2: 1qr1 D:1-181

Lineage for d1qr1d2 (1qr1 D:1-181)

1. Root: SCOP 1.71

2. Class d: Alpha and beta proteins (a+b) [53931] (286 folds)

3. Fold d.19: MHC antigen-recognition domain [54451] (1 superfamily)
   dimeric

4. Superfamily d.19.1: MHC antigen-recognition domain [54452] (1 family)

5. Family d.19.1.1: MHC antigen-recognition domain [54453] (12 proteins)

6. Protein Class I MHC, alpha-1 and alpha-2 domains [54468] (22 species)

7. Species Human (Homo sapiens), HLA-A2.1 [TaxId:9606] [54470] (36 PDB entries)

8. Domain d1qr1d2: 1qr1 D:1-181 [38246]
   Other proteins in same PDB: d1qr1a1, d1qr1b_, d1qr1d1, d1qr1e_

Details for d1qr1d2

PDB Entry: 1qr1, 2.4 Å

PDB Description: poor binding of a her-2/neu epitope (gp2) to hla-a2.1 is due to a lack of interactions in the center of the peptide

SCOP Domain Sequences for d1qr1d2:

Sequence; same for both SEQRES and ATOM records:

>d1qr1d2 d.19.1.1 (D:1-181) Class I MHC, alpha-1 and alpha-2 domains {Human (Homo sapiens), HLA-A2.1}
gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
r

Timeline for d1qr1d2:

• d1qr1d2 first appeared (with stable ids) in SCOP 1.55
  
• d1qr1d2 appears in SCOP 1.69
  
• d1qr1d2 appears in SCOP 1.73
  
• d1qr1d2 appears in the current release, SCOPe 2.08