SCOPe 2.08: Domain d6u6fb1: 6u6f B:171-321

Lineage for d6u6fb1 (6u6f B:171-321)

1. Root: SCOPe 2.08

2. Class f: Membrane and cell surface proteins and peptides [56835] (69 folds)

3. Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
   multi-helical domains of various folds which is thought to unfold in the membrane

4. Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (2 families)
   PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain

5. Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (11 proteins)
   Pfam PF00452

6. Protein EAT/MCL-1 (Myeloid cell leukemia sequence 1) [118212] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [188549] (62 PDB entries)

8. Domain d6u6fb1: 6u6f B:171-321 [381958]
   Other proteins in same PDB: d6u6fb2
   automated match to d2kbwa_
   complexed with pzy

Details for d6u6fb1

PDB Entry: 6u6f, 2.9 Å

PDB Description: the crystal structure of anti-apoptotic mcl-1 protein in complex with 2, 5-substituted benzoic acid inhibitor 21

PDB Compounds: (B:) Induced myeloid leukemia cell differentiation protein Mcl-1

SCOPe Domain Sequences for d6u6fb1:

Sequence; same for both SEQRES and ATOM records:

>d6u6fb1 f.1.4.1 (B:171-321) EAT/MCL-1 (Myeloid cell leukemia sequence 1) {Human (Homo sapiens) [TaxId: 9606]}
edelyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqg
mlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepl
aesitdvlvrtkrdwlvkqrgwdgfveffhv

Timeline for d6u6fb1:

• d6u6fb1 first appeared in SCOPe 2.07