SCOPe 2.07: Domain d6vnnb_: 6vnn B:

Lineage for d6vnnb_ (6vnn B:)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (82 PDB entries)
   Uniprot P03372 307-551

8. Domain d6vnnb_: 6vnn B: [380584]
   automated match to d3erta_
   complexed with r54

Details for d6vnnb_

PDB Entry: 6vnn, 1.64 Å

PDB Description: estrogen receptor alpha ligand binding domain in complex with a methylated lasofoxifene derivative that increases receptor resonance time in the nucleus of breast cancer cells

PDB Compounds: (B:) Estrogen receptor

SCOPe Domain Sequences for d6vnnb_:

Sequence, based on SEQRES records:

>d6vnnb_ a.123.1.1 (B:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
alsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvpg
fvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifd
mllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtl
ihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemld

Sequence, based on observed residues (ATOM records):

>d6vnnb_ a.123.1.1 (B:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
alsltadqmvsalldaeppilyseydptrpfsmmglltnladrelvhminwakrvpgfvd
ltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmll
atssrfrmmnlqgeefvclksiillnsgvytftlksleekdhihrvldkitdtlihlmak
agltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemld

Timeline for d6vnnb_:

• d6vnnb_ is new in SCOPe 2.07-stable
  
• d6vnnb_ does not appear in SCOPe 2.08