SCOPe 2.08: Domain d6vg0c_: 6vg0 C:

Lineage for d6vg0c_ (6vg0 C:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins)
   the active site is between the two identical subunits

6. Protein NADP-dependent isocitrate dehydrogenase [82524] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [110715] (31 PDB entries)
   Uniprot O75874

8. Domain d6vg0c_: 6vg0 C: [380257]
   Other proteins in same PDB: d6vg0b2
   automated match to d1t0la_
   complexed with ndp, qwm; mutant

Details for d6vg0c_

PDB Entry: 6vg0, 2.66 Å

PDB Description: crystal structure of human cytosolic isocitrate dehydrogenase (idh1) r132h mutant in complex with nadph and agi-15056

PDB Compounds: (C:) isocitrate dehydrogenase [nadp] cytoplasmic

SCOPe Domain Sequences for d6vg0c_:

Sequence, based on SEQRES records:

>d6vg0c_ c.77.1.1 (C:) NADP-dependent isocitrate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
isggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaaeai
kkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvsgw
vkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgmyn
qdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaqki
wyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgktve
aeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleevsi
etieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaq

Sequence, based on observed residues (ATOM records):

>d6vg0c_ c.77.1.1 (C:) NADP-dependent isocitrate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
isggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaaeai
kkhnvgvkcatitkrveefklkqmwkspngtirnilggtvfreaiickniprlvsgwvkp
iiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgmynqdk
siedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaqkiwye
hrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgktveaea
ahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleevsieti
eagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaq

Timeline for d6vg0c_:

• d6vg0c_ first appeared in SCOPe 2.07