SCOPe 2.08: Domain d6v6la_: 6v6l A:

Lineage for d6v6la_ (6v6l A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Glycogen synthase kinase-3 beta (Gsk3b) [69823] (2 species)
   CMGC group; GSK3 subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [69824] (57 PDB entries)
   Uniprot P49841 35-383 ! Uniprot P49841 35-384

8. Domain d6v6la_: 6v6l A: [379169]
   automated match to d1j1ba_
   complexed with po4, qqa

Details for d6v6la_

PDB Entry: 6v6l, 2.19 Å

PDB Description: co-structure of human glycogen synthase kinase beta with 1-(6-((2-((6- amino-5-nitropyridin-2-yl)amino)ethyl)amino)-2-(2,4-dichlorophenyl) pyridin-3-yl)-4-methylpiperazin-2-one

PDB Compounds: (A:) Glycogen synthase kinase-3 beta

SCOPe Domain Sequences for d6v6la_:

Sequence, based on SEQRES records:

>d6v6la_ d.144.1.7 (A:) Glycogen synthase kinase-3 beta (Gsk3b) {Human (Homo sapiens) [TaxId: 9606]}
vttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfknr
elqimrkldhcnivrlryffyssgekkdevylnlvldyvpetvyrvarhysrakqtlpvi
yvklymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsy
icsryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtp
treqiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleaca
hsffdelrdpnvklpngrdtpalfnfttqelssnpplatilipphari

Sequence, based on observed residues (ATOM records):

>d6v6la_ d.144.1.7 (A:) Glycogen synthase kinase-3 beta (Gsk3b) {Human (Homo sapiens) [TaxId: 9606]}
vttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrelqi
mrkldhcnivrlryffyssgekkdevylnlvldyvpetvyrvarhysrakqtlpviyvkl
ymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyicsr
yyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtptreq
iremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleacahsff
delrdpnvklpngrdtpalfnfttqelssnpplatilipphari

Timeline for d6v6la_:

• d6v6la_ first appeared in SCOPe 2.07