SCOPe 2.08: Domain d6t3ba1: 6t3b A:146-320

Lineage for d6t3ba1 (6t3b A:146-320)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.15: beta-Grasp (ubiquitin-like) [54235] (15 superfamilies)
   core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

4. Superfamily d.15.1: Ubiquitin-like [54236] (11 families)

5. Family d.15.1.5: Ras-binding domain, RBD [54263] (14 proteins)
   contains Pfam PF00788 and Pfam PF02196

6. Protein Phoshoinositide 3-kinase (PI3K) [54274] (2 species)
   includes parts of the flanking linkers

7. Species Human (Homo sapiens) [TaxId:9606] [54276] (77 PDB entries)

8. Domain d6t3ba1: 6t3b A:146-320 [378758]
   Other proteins in same PDB: d6t3ba2, d6t3ba3
   automated match to d1he8a3
   complexed with m9t
   has additional insertions and/or extensions that are not grouped together

Details for d6t3ba1

PDB Entry: 6t3b, 3.01 Å

PDB Description: crystal structure of pi3kgamma with a dihydropurinone inhibitor (compound 4)

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d6t3ba1:

Sequence, based on SEQRES records:

>d6t3ba1 d.15.1.5 (A:146-320) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
esqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvtsk
plpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdipesq
seqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrk

Sequence, based on observed residues (ATOM records):

>d6t3ba1 d.15.1.5 (A:146-320) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
esqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvtsk
plpeylwkkianncifivihrttsqtikvspddtpgailqdfvlrvcgrdeylvgetpik
nfqwvrhclkngeeihvvldtppdpaldevrk

Timeline for d6t3ba1:

• d6t3ba1 first appeared in SCOPe 2.07