SCOPe 2.08: Domain d6gwqa_: 6gwq A:

Lineage for d6gwqa_ (6gwq A:)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.1: Serpins [56573] (1 superfamily)
   contains a cluster of helices and a beta-sandwich

4. Superfamily e.1.1: Serpins [56574] (2 families)

5. Family e.1.1.1: Serpins [56575] (17 proteins)
   automatically mapped to Pfam PF00079

6. Protein Plasminogen activator inhibitor-1 [56587] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56588] (21 PDB entries)

8. Domain d6gwqa_: 6gwq A: [378696]
   Other proteins in same PDB: d6gwqb_
   automated match to d1lj5a_

Details for d6gwqa_

PDB Entry: 6gwq, 2.32 Å

PDB Description: crystal structure of stabilized active plasminogen activator inhibitor-1 (pai-1-stab) in complex with an inhibitory nanobody (vhh- 2g-42)

PDB Compounds: (A:) plasminogen activator inhibitor-1

SCOPe Domain Sequences for d6gwqa_:

Sequence, based on SEQRES records:

>d6gwqa_ e.1.1.1 (A:) Plasminogen activator inhibitor-1 {Human (Homo sapiens) [TaxId: 9606]}
vhhppsyvahlasdfgvrvfqqvaqaskdrnvvfspygvasvlamlqlttggetqqqiqa
amgfkiddkgmapalrhlykelmgpwnkdeisttdaifvqrdlklvqgfmphffrlfrst
vkqvdfseverarfiindwvkthtkgmishllgtgavdqltrlvlvnalyfngqwktpfp
dssthrrlfhksdgstvsvpmmaqtnkfnytefttpdghyydilelpyhgdtlsmfiaap
yekevplsaltnilsaqlishwkgnmtrlprllvlpkfsletevdlrkplenlgmtdmfr
pfqadftslsdqeplhvalalqkvkievnesgtvassstavivsarmapeeiiidrpflf
vvrhnptgtvlfmgqvmep

Sequence, based on observed residues (ATOM records):

>d6gwqa_ e.1.1.1 (A:) Plasminogen activator inhibitor-1 {Human (Homo sapiens) [TaxId: 9606]}
vhhppsyvahlasdfgvrvfqqvaqaskdrnvvfspygvasvlamlqlttggetqqqiqa
amgfkiddkgmapalrhlykelmgpwdeisttdaifvqrdlklvqgfmphffrlfrstvk
qvdfseverarfiindwvkthtkgmishllgtgavdqltrlvlvnalyfngqwktpfpds
sthrrlfhksdgstvsvpmmaqtnkfnytefttpdghyydilelpyhgdtlsmfiaapye
kevplsaltnilsaqlishwkgnmtrlprllvlpkfsletevdlrkplenlgmtdmfrpf
qadftslsdqeplhvalalqkvkievnespeeiiidrpflfvvrhnptgtvlfmgqvmep

Timeline for d6gwqa_:

• d6gwqa_ first appeared in SCOPe 2.07