SCOPe 2.08: Domain d6o9xa_: 6o9x A:

Lineage for d6o9xa_ (6o9x A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.50: Macro domain-like [52948] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 6 strands, order 165243, strand 3 is antiparallel to the rest

4. Superfamily c.50.1: Macro domain-like [52949] (4 families)

5. Family c.50.1.3: Poly(ADP-ribose) glycohydrolase (PARG) catalytic domain-like [310642] (2 proteins)
   Pfam PF05028
   Contains N- and C-terminal extensions to macrodomain, including Tyr clasp, discussed in PubMed 22609859

6. Protein Poly(ADP-ribose) glycohydrolase (PARG) catalytic domain [310785] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [324080] (19 PDB entries)

8. Domain d6o9xa_: 6o9x A: [378600]
   automated match to d3ueka_
   complexed with m0s

Details for d6o9xa_

PDB Entry: 6o9x, 1.7 Å

PDB Description: structure of human parg complexed with ja2-4

PDB Compounds: (A:) Poly(ADP-ribose) glycohydrolase

SCOPe Domain Sequences for d6o9xa_:

Sequence, based on SEQRES records:

>d6o9xa_ c.50.1.3 (A:) Poly(ADP-ribose) glycohydrolase (PARG) catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
dkkwlgtpieemrrmprcgirlpllrpsanhtvtirvdllragevpkpfpthykdlwdnk
hvkmpcseqnlypvedengertagsrweliqtallnkftrpqnlkdailkynvayskkwd
ftalidfwdkvleeaeaqhlyqsilpdmvkialclpnictqpipllaaamnhsitmsqeq
iasllanaffctfprrnakmkseyssypdinfnrlfegrssrkpeklktlfcyfrrvtaa
aptglvtftrqsledfpewercekpltrlhvtyegtieengqgmlqvdfanrfvgggvts
aglvqeeirflinpeliisrlftevldhnecliitgteqyseytgyaetyrwsrshedgs
erddwqrrcteivaidalhfrryldqfvpekmrrelnkaycgflrpgvssenlsavatgn
wgcgafggdarlkaliqilaaaaaerdvvyftfgdselmrdiysmhiflterkltvgdvy
klllryyneecrncstpgpdiklypfiyhavesc

Sequence, based on observed residues (ATOM records):

>d6o9xa_ c.50.1.3 (A:) Poly(ADP-ribose) glycohydrolase (PARG) catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
dkkwlgtpieemrrmprcgirlpllrpsanhtvtirvdllragevpkpfpthykdlwdnk
hvkmpcseqnlypvtagsrweliqtallnkftrpqnlkdailkynvayskkwdftalidf
wdkvleeaeaqhlyqsilpdmvkialclpnictqpipllaaamnhsitmsqeqiasllan
affctfprrnakyssypdinfnrlfegrssrkpeklktlfcyfrrvtaaaptglvtftrq
sledfpewercekpltrlhvtyegtieengqgmlqvdfanrfvgggvtsaglvqeeirfl
inpeliisrlftevldhnecliitgteqyseytgyaetyrwsrshedgserddwqrrcte
ivaidalhfrryldqfvpekmrrelnkaycgflrpgvssenlsavatgnwgcgafggdar
lkaliqilaaaaaerdvvyftfgdselmrdiysmhiflterkltvgdvyklllryyneec
rncstpgpdiklypfiyhavesc

Timeline for d6o9xa_:

• d6o9xa_ first appeared in SCOPe 2.07