SCOPe 2.08: Domain d6itva_: 6itv A:

Lineage for d6itva_ (6itv A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein c-KIT receptor [103296] (1 species)
   PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103297] (18 PDB entries)
   Uniprot P10721 547-935

8. Domain d6itva_: 6itv A: [377303]
   automated match to d1t45a_
   complexed with awo

Details for d6itva_

PDB Entry: 6itv, 1.88 Å

PDB Description: crystal structure of activated c-kit in complex with compound

PDB Compounds: (A:) Mast/stem cell growth factor receptor Kit

SCOPe Domain Sequences for d6itva_:

Sequence, based on SEQRES records:

>d6itva_ d.144.1.7 (A:) c-KIT receptor {Human (Homo sapiens) [TaxId: 9606]}
vyidptqlpydhkwefprnrlsfgktlgagafgkvveataygliksdaamtvavkmlkps
ahlterealmselkvlsylgnhmnivnllgactiggptlviteyccygdllnflrrkrds
ficsktspaimeddelaldledllsfsyqvakgmaflaskncihrdlaarnillthgrit
kicdfglardikndsnyvvkgnarlpvkwmapesifncvytfesdvwsygiflwelfslg
sspypgmpvdskfykmikegfrmlspehapaemydimktcwdadplkrptfkqivqliek
qisestnhi

Sequence, based on observed residues (ATOM records):

>d6itva_ d.144.1.7 (A:) c-KIT receptor {Human (Homo sapiens) [TaxId: 9606]}
vyidptqlpydhkwefprnrlsfgktlgagafgkvveataygliksdaamtvavkmlkps
ahlterealmselkvlsylgnhmnivnllgactiggptlviteyccygdllnflrrkrds
eddelaldledllsfsyqvakgmaflaskncihrdlaarnillthgritkicdfglardi
kndsnyvvkgnarlpvkwmapesifncvytfesdvwsygiflwelfslgsspypgmpvds
kfykmikegfrmlspehapaemydimktcwdadplkrptfkqivqliekqisestnhi

Timeline for d6itva_:

• d6itva_ first appeared in SCOPe 2.07