SCOPe 2.08: Domain d6s9ca1: 6s9c A:696-1019

Lineage for d6s9ca1 (6s9c A:696-1019)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
   PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82796] (133 PDB entries)
   Uniprot P00533 702-1018

8. Domain d6s9ca1: 6s9c A:696-1019 [377185]
   Other proteins in same PDB: d6s9ca2
   automated match to d3ikaa_
   complexed with dms, l1k

Details for d6s9ca1

PDB Entry: 6s9c, 2.73 Å

PDB Description: egfr-kinase in complex with compound 5

PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d6s9ca1:

Sequence, based on SEQRES records:

>d6s9ca1 d.144.1.7 (A:696-1019) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaaaaeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptds
nfyralmdeedmddvvdadeylip

Sequence, based on observed residues (ATOM records):

>d6s9ca1 d.144.1.7 (A:696-1019) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelrtspkank
eildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnw
cvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllkvpikwmalesilhr
iythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimvk
cwmidadsrpkfreliiefskmardpqrylviqgdermhlpspeedmddvvdadeylip

Timeline for d6s9ca1:

• d6s9ca1 first appeared in SCOPe 2.07