SCOPe 2.08: Domain d6q2tb1: 6q2t B:61-502

Lineage for d6q2tb1 (6q2t B:61-502)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.104: Cytochrome P450 [48263] (1 superfamily)
   multihelical

4. Superfamily a.104.1: Cytochrome P450 [48264] (2 families)

5. Family a.104.1.0: automated matches [191509] (1 protein)
   not a true family

6. Protein automated matches [190847] (99 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [196470] (52 PDB entries)

8. Domain d6q2tb1: 6q2t B:61-502 [376858]
   Other proteins in same PDB: d6q2ta2, d6q2tb2
   automated match to d3khma_
   complexed with dxc, hem, pjm

Details for d6q2tb1

PDB Entry: 6q2t, 2.8 Å

PDB Description: human sterol 14a-demethylase (cyp51) in complex with the functionally irreversible inhibitor (r)-n-(1-(3-chloro-4'-fluoro-[1,1'-biphenyl]- 4-yl)-2-(1h-imidazol-1-yl)ethyl)-4-(5-(3-fluoro-5-(5-fluoropyrimidin- 4-yl)phenyl)-1,3,4-oxadiazol-2-yl)benzamide

PDB Compounds: (B:) Lanosterol 14-alpha demethylase

SCOPe Domain Sequences for d6q2tb1:

Sequence; same for both SEQRES and ATOM records:

>d6q2tb1 a.104.1.0 (B:61-502) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ppyifspipflghaiafgkspieflenayekygpvfsftmvgktftyllgsdaaallfns
knedlnaedvysrlttpvfgkgvaydvpnpvfleqkkmlksglniahfkqhvsiieketk
eyfeswgesgeknvfealseliiltashclhgkeirsqlnekvaqlyadldggfshaawl
lpgwlplpsfrrrdrahreikdifykaiqkrrqsqekiddilqtlldatykdgrpltdde
vagmliglllagqhtssttsawmgfflardktlqkkcyleqktvcgenlppltydqlkdl
nlldrciketlrlrppimimmrmartpqtvagytippghqvcvsptvnqrlkdswverld
fnpdrylqdnpasgekfayvpfgagrhrcigenfayvqiktiwstmlrlyefdlidgyfp
tvnyttmihtpenpvirykrrs

Timeline for d6q2tb1:

• d6q2tb1 first appeared in SCOPe 2.07