Lineage for d1e8za3 (1e8z A:144-322)

  1. Root: SCOP 1.71
  2. 595667Class d: Alpha and beta proteins (a+b) [53931] (286 folds)
  3. 598488Fold d.15: beta-Grasp (ubiquitin-like) [54235] (12 superfamilies)
    core: beta(2)-alpha-beta(2); mixed beta-sheet 2143
  4. 598489Superfamily d.15.1: Ubiquitin-like [54236] (6 families) (S)
  5. 598694Family d.15.1.5: Ras-binding domain, RBD [54263] (9 proteins)
    contains Pfam 00788 and Pfam 02196
  6. 598705Protein Phoshoinositide 3-kinase (PI3K) [54274] (2 species)
    includes parts of the flanking linkers
  7. 598706Species Human (Homo sapiens) [TaxId:9606] [54276] (3 PDB entries)
  8. 598708Domain d1e8za3: 1e8z A:144-322 [37636]
    Other proteins in same PDB: d1e8za1, d1e8za2, d1e8za4
    complexed with stu; mutant

Details for d1e8za3

PDB Entry: 1e8z (more details), 2.4 Å

PDB Description: structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, ly294002, quercetin, myricetin and staurosporine
PDB Compounds: (A:)

SCOP Domain Sequences for d1e8za3:

Sequence, based on SEQRES records: (download)

>d1e8za3 d.15.1.5 (A:144-322) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens)}
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdipe
sqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkee

Sequence, based on observed residues (ATOM records): (download)

>d1e8za3 d.15.1.5 (A:144-322) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens)}
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakdfvlrvcgr
deylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkee

SCOP Domain Coordinates for d1e8za3:

Click to download the PDB-style file with coordinates for d1e8za3.
(The format of our PDB-style files is described here.)

Timeline for d1e8za3: