SCOP 1.69: Domain d1e8ya3: 1e8y A:143-322

Lineage for d1e8ya3 (1e8y A:143-322)

1. Root: SCOP 1.69

2. Class d: Alpha and beta proteins (a+b) [53931] (279 folds)

3. Fold d.15: beta-Grasp (ubiquitin-like) [54235] (12 superfamilies)
   core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

4. Superfamily d.15.1: Ubiquitin-like [54236] (6 families)

5. Family d.15.1.5: Ras-binding domain, RBD [54263] (6 proteins)

6. Protein Phoshoinositide 3-kinase (PI3K) [54274] (2 species)
   includes parts of the flanking linkers

7. Species Human (Homo sapiens) [TaxId:9606] [54276] (3 PDB entries)

8. Domain d1e8ya3: 1e8y A:143-322 [37635]
   Other proteins in same PDB: d1e8ya1, d1e8ya2, d1e8ya4

Details for d1e8ya3

PDB Entry: 1e8y, 2 Å

PDB Description: structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, ly294002, quercetin, myricetin and staurosporine

SCOP Domain Sequences for d1e8ya3:

Sequence, based on SEQRES records:

>d1e8ya3 d.15.1.5 (A:143-322) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens)}
mseesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwv
tskplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdip
esqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkee

Sequence, based on observed residues (ATOM records):

>d1e8ya3 d.15.1.5 (A:143-322) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens)}
mseesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwv
tskplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmaeqdfvlrvc
grdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkee

Timeline for d1e8ya3:

• d1e8ya3 first appeared (with stable ids) in SCOP 1.55
  
• d1e8ya3 appears in SCOP 1.67
  
• d1e8ya3 appears in SCOP 1.71
  
• d1e8ya3 appears in the current release, SCOPe 2.08